diff --git a/packages/compiler-sfc/__tests__/__snapshots__/compileScript.spec.ts.snap b/packages/compiler-sfc/__tests__/__snapshots__/compileScript.spec.ts.snap
index 4164124a..36604db2 100644
--- a/packages/compiler-sfc/__tests__/__snapshots__/compileScript.spec.ts.snap
+++ b/packages/compiler-sfc/__tests__/__snapshots__/compileScript.spec.ts.snap
@@ -108,6 +108,38 @@ return { props, bar }
 }"
 `;
 
+exports[`SFC compile <script setup> defineProps/defineEmits in multi-variable decalration (full removal) 1`] = `
+"export default {
+  props: ['item'],
+  emits: ['a'],
+  setup(__props, { expose, emit }) {
+  expose()
+
+const props = __props
+    
+    
+return { props, emit }
+}
+
+}"
+`;
+
+exports[`SFC compile <script setup> defineProps/defineEmits in multi-variable decalration 1`] = `
+"export default {
+  props: ['item'],
+  emits: ['a'],
+  setup(__props, { expose, emit }) {
+  expose()
+
+const props = __props
+    const a = 1;
+    
+return { props, a, emit }
+}
+
+}"
+`;
+
 exports[`SFC compile <script setup> errors should allow defineProps/Emit() referencing imported binding 1`] = `
 "import { bar } from './bar'
         
diff --git a/packages/compiler-sfc/__tests__/compileScript.spec.ts b/packages/compiler-sfc/__tests__/compileScript.spec.ts
index f59ee13f..caf56fab 100644
--- a/packages/compiler-sfc/__tests__/compileScript.spec.ts
+++ b/packages/compiler-sfc/__tests__/compileScript.spec.ts
@@ -97,6 +97,32 @@ const myEmit = defineEmits(['foo', 'bar'])
   emits: ['foo', 'bar'],`)
   })
 
+  test('defineProps/defineEmits in multi-variable decalration', () => {
+    const { content } = compile(`
+    <script setup>
+    const props = defineProps(['item']),
+      a = 1,
+      emit = defineEmits(['a']);
+    </script>
+  `)
+    assertCode(content)
+    expect(content).toMatch(`const a = 1;`) // test correct removal
+    expect(content).toMatch(`props: ['item'],`)
+    expect(content).toMatch(`emits: ['a'],`)
+  })
+
+  test('defineProps/defineEmits in multi-variable decalration (full removal)', () => {
+    const { content } = compile(`
+    <script setup>
+    const props = defineProps(['item']),
+          emit = defineEmits(['a']);
+    </script>
+  `)
+    assertCode(content)
+    expect(content).toMatch(`props: ['item'],`)
+    expect(content).toMatch(`emits: ['a'],`)
+  })
+
   test('defineExpose()', () => {
     const { content } = compile(`
 <script setup>
diff --git a/packages/compiler-sfc/src/compileScript.ts b/packages/compiler-sfc/src/compileScript.ts
index 08f0c2d4..de688acd 100644
--- a/packages/compiler-sfc/src/compileScript.ts
+++ b/packages/compiler-sfc/src/compileScript.ts
@@ -820,7 +820,10 @@ export function compileScript(
     }
 
     if (node.type === 'VariableDeclaration' && !node.declare) {
-      for (const decl of node.declarations) {
+      const total = node.declarations.length
+      let left = total
+      for (let i = 0; i < total; i++) {
+        const decl = node.declarations[i]
         if (decl.init) {
           const isDefineProps =
             processDefineProps(decl.init) || processWithDefaults(decl.init)
@@ -838,10 +841,20 @@ export function compileScript(
             )
           }
           if (isDefineProps || isDefineEmits)
-            if (node.declarations.length === 1) {
+            if (left === 1) {
               s.remove(node.start! + startOffset, node.end! + startOffset)
             } else {
-              s.remove(decl.start! + startOffset, decl.end! + startOffset)
+              let start = decl.start! + startOffset
+              let end = decl.end! + startOffset
+              if (i < total - 1) {
+                // not the last one, locate the start of the next
+                end = node.declarations[i + 1].start! + startOffset
+              } else {
+                // last one, locate the end of the prev
+                start = node.declarations[i - 1].end! + startOffset
+              }
+              s.remove(start, end)
+              left--
             }
         }
       }